- Title
- Immunosuppression for in vivo research: State-of-The-Art protocols and experimental approaches
- Creator
- Diehl, Rita; Ferrara, Fabienne; Müller, Claudia; Dreyer, Antje Y.; McLeod, Damian D.; Fricke, Stephan; Boltze, Johannes
- Relation
- Cellular and Molecular Immunology Vol. 14, Issue 2, p. 146-179
- Publisher Link
- http://dx.doi.org/10.1038/cmi.2016.39
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2017
- Description
- Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models before clinical translation. Because these strategies require immunosuppression in most cases, immunosuppressive protocols are a key element in transplantation experiments. However, standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species. Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation. This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects. It also summarizes contemporary knowledge of novel immunomodulatory strategies, such as the use of mesenchymal stem cells or antibodies. Thus, this review is intended to serve as a state-of-The-Art compendium for researchers to refine applied experimental immunosuppression and immunomodulation strategies to enhance the predictive value of preclinical transplantation studies.
- Subject
- animal models; immunomodulation; immunosuppression; transplantation; translational research
- Identifier
- http://hdl.handle.net/1959.13/1391190
- Identifier
- uon:33182
- Identifier
- ISSN:1672-7681
- Rights
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0
- Language
- eng
- Full Text
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